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UCI Faculty Profile
Pulmonary free radical biology primarily relating to various types of the cytochrome P-450 enzyme system are the major fields of interest in this laboratory. These studies are related to the understanding of toxicity of environmental pollutants, oxygen toxicity and ARDS. Studies are extended for evaluation of sexual differentiation in adulthood after neonatal insults with xenobiotics and hyperoxia.
- Kikkawa, Y. Diverse role of pulmonary cytochrome P450 system. Editorial. Lab. Inv. 67:535-539, 1992.
- Sakai, H., S.S. Park, Y. Kikkawa. Differential oxidase activity of hepatic and pulmonary microsomal cytochrome P450 isozymes after treatment with cytochrome P450 inducers. Biochem. Biophys. Res. Comm. 187:1262-1269, 1992.
- Kikkawa, Y., I. Fujita, R.K. Sindhu. Neonatal Hyperoxia and Cytochrome P450 Imprinting in Adulthood. Ped. Res. 35:255-258, 1994.
- Fujita, I., R.K. Sindhu, Y. Kikkawa. Hepatic cytochrome P450 enzyme imprinting in adult rats by neonatal benzo[a]pyrene administration. Ped. Res. 37:646-651, 1995.
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