M.D., Yale Medical School, 1968

UCI Faculty Profile

Current research interests involve the mechanisms through which macrophages can modulate the activities of the immune system. These cells can both enhance immune responses as well as inhibit immunity. We have previously identified that a cloned suppressor hybridoma cell line induces natural suppression through the release of a cytokine, macrophage colony stimulating factor (M-CSF). M-CSF activated macrophages suppressed lymphocytic responses through a non-apoptotic pathways. This animal model may be the first in vitro model of a human disease known as Rosai-Dorfman disease. Besides making a secreted form of M-CSF, our cell line possesses another isoform of M-CSF which resides on the membrane of the cell. Macrophages now have the ability to kill those tumor cells which possess.

The hypothesis that we are testing is that tumor cells which possess membrane bound M-CSF are able to stimulate macrophages into killing those cells. Macrophages which have killed these tumor cells are now able to stimulate the host's immune system, there by creating a tumor vaccine.

• Jadus, M.R., R. Pai, E. Horansky, H.T. Wepsic, M.A. Kirschenbaum, V.S. Kamanna. Hematopoietic colony stimulatory factor production by a murine mesangial cell line: Gene expression and biological activity. Biochemica et Biophysica Acta. 1224:181-18 8, 1994.
  
  
• Gelfand, R., H.T. Wepsic, L.N. Parker, M.R. Jadus. Prostaglandin E2 induce upregulation of murine macrophage beta endorphin receptors. Immunology Letters. 45:143-148, 1995.
  
  
• Jadus, M.R., M.R. Irwin, B.E. Barton, M.N. Irwin, H.T. Wepsic. The identification of the neonatal NBXFO hybridoma cell and its mediator. Comparative and Developmental Immunology, (manuscript accepted for publication), Feb. 1995.
  
  
• Jadus, M.R., S. Sekhon, B.E. Barton, H.T. Wepsic. Macrophage colony stimulating factor activated bone marrow macrophages suppress lymphocytic responses through phagocytosis: a tentative in vitro model of Rosai-Dorfman Disease. Journal of Leukocyte Biology, (manuscript accepted for publication), Feb. 1995.
  
  
• Jadus, M.R., M.N. Irwin, M.R. Irwin, H.T. Wepsic. The membrane isoform of macrophage colony stimulating factor allows the cytotoxic signal to be delivered by killer macrophages. Manuscript in preparation (1995).