M.D., University of Belgrade Medical School, Yugoslavia, 1968
Ph.D., University of Montreal, Canada, 1973
M.P.H., Harvard School of Public Health, Boston, MA, 1983

UCI Faculty Profile

Dr. Szabo's laboratory is concerned with the field of the pathogenesis of gastrointestinal (GI) ulceration, especially of duodenal ulcer. Most of the seminal contributions which evolved from his laboratory relate to the experimental models that he developed and mechanisms related to duodenal ulcers. For the past decade Dr. Szabo systematically investigated the underlying mechanisms involved in experimental ulcers using an array of morphological, functional, biochemical, molecular biologic and pharmacologic methods of approach. More recently, he applied his knowledge of angiogenesis, growth factors and gene expression to the field of experimental ulcers. This provided new venues to explain the mechanisms of GI ulceration and the action of drugs such as sucralfate and potential new therapeutic strategies for healing ulcers.

1. Giampaolo, C., A.T. Gray, R.A. Olshen, S. Szabo. Predicting chemically induced duodenal ulcer and adrenal necrosis with classification trees. Proc. Natl. Acad. Sci., USA, 88:6298-6302, 1991.
   
   
2. Szabo, S., J. Folkman, P. Vattay, R.E. Morales, G.S. Pinkus, K. Kato. Accelerated healing of duodenal ulcers by oral administration of a mutein of basic fibroblast growth factor in rats. Gastroenterology. 106:1106-111, 1994.
   
   
3. Glavin, G.B., S. Szabo, B.R. Johnson, P.L. Xing, R.E. Morales, M. Plebani, L. Nagy. Isolated rat gastric mucosal cells: optimal conditions for cell harvesting, measures of viability and direct cytoprotection. J. Pharmacol Exper. Ther. 276:1174-1179, 1996.
   
   
4. Nagy, L., S. Kusstatscher, P.V. Hauschka, S. Szabo. Role of cysteine proteases and protease inhibitors in gastric mucosal damage induced by ethanol or ammonia in the rat. J. Clin. Invest. 98:1047-1054, 1996.
   
   
5. Nagy, L., B.R. Johnson, P. Hauschka, S. Szabo. Characterization of proteases and protease inhibitors in the rat stomach. Am J. Physiol. 272:G1151-1158, 1997.
   
   
6. Szabo, S., A. Vincze, Z. Sandor, M. Jadus, Z. Gombos, A. Pedram, E. Levin, J. Hagar, G. Iaquinto. Vascular approach to gastroduodenal ulceration: new studies with endothelins and VEGF. Dig. Dis. Sci. 43:40S-45S, 1998.