M.D., Indiana University, 1949

UCI Faculty Profile 

Research interests focus on the structure-function studies on thrombin-like enzymes and fibrinogen, employing methods of protein chemistry and DNA sequencing. Physicochemical and electron microscopic studies on fibrin formation are also being conducted.

• Pirkle, H., A. Henschen, I. Theodor and J. Cunnan. Isoforms of a highly specific B-chain fibrinogenase from the venom of Crotalus atrox, Blood Coag. Fibrinolys. 1:453-455, 1990.
  
  
• Pirkle, H. and I. Theodor. Thrombin-like enzymes: Structure and function. Adv. Exper. Med. Biol. 281:165-175, 1991.
  
  
• Henschen, A.H., K.G. Krieglstein, R.E. Baumann, and H. Pirkle. Normale und abnormale Varianten des humanen Fibrinogens, in "22. Hamophilie-Symposion, Hamburg 1991," G. Landbeck, I. Scharrer and W. Schramm (eds.) Springer-Verlag, Berlin, 1992, pp. 163-173.
  
  
• Pirkle, H., I. Theodor, and A. Henschen. Crotalase, a fibrinogen-clotting venom enzyme: Primary structure and evidence for lack of a fibrinogen recognition exosite homologous to that of thrombin. Haemostas. 26 (suppl 3): 452, 1996.
  
  
• Massova, I., H. Pirkle, B.F.P. Edwards and S. Mobashery. Insights into the three-dimensional structure of crotalase: Implications for biological activity and substrate specificity. Bioorg. Med. Chem. Lett. 7: 3139-3144, 1997.
  
  
• Pirkle, H. and I. Theodor. Thrombin-like enzymes, in "Snake Venom Enzymes," G.S. Bailey (ed.), Alaken, Inc., Fort Collins, CO 1998, pp. 39-69.
  
  
• Pirkle, H. and F.S. Markland, Jr. Venombin AB, in "Handbook of Proteolytic Enzymes," A.J. Barrett, F. Woessner, and N. Rawlings (eds.) Academic Press, London, 1998, pp. 223-225.
  
  
• Markland, Jr., F.S. and H. Pirkle. Venombin A, in "Handbook of Proteolytic Enzymes," A.J. Barrett, F. Woessner, and N. Rawlings (eds.) Academic Press, London, 1998, pp. 216-223.
  
  
• Pirkle, H. Thrombin-like enzymes from snake venoms: An updated inventory. Thrombos. Haemostas. 79: 675-683, 1998.
  
  
• Henschen-Edman, A.H., I. Theodor, B.F.P. Edwards, and H. Pirkle: Crotalase, a fibrinogen-clotting snake venom enzyme: Primary structure and evidence for a fibrogen recognition exosite different from thrombin. Thrombos. Haemostas. 81:81-86, 1999.