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Link to CV
UCI Faculty Profile
Currently attempts are being made to vaccinate experimental animals with the purified major outer membrane protein (MOMP) of the C. trachomatis mouse pneumonitis biovar. Antibodies to this protein have been shown to occur in a majority of chlamydial infections and furthermore polyclonal and monoclonal antibodies to the MOMP are known to neutralize chlamydial infectivity in vitro. In the animal model mice will be inoculated with the purified MOMP and then they will be challenged with infectious Chlamydiae in the genital tract. The ability of the vaccine to prevent infection and/or to preserve fertility will be determined.
The clinical laboratory research efforts have focused on improving the diagnostic methods for the detection of C. trachomatis in clinical specimens. In this regard, the application of the polymerase chain reaction for the detection of C. trachomatis has been explored.
- Khamesipour A., S. Pal, E.M. Peterson and L.M. de la Maza. Induction of infertility by the Chlamydia trachomatis mouse pneumonitis biovar in strains of mice that differ in their response to the 60 kDa heat shock protein. J. Reproduct. Infert. 101:287-294, 1994.
- Pal, S., T.J. Fielder, E.M. Peterson and L.M. de la Maza. Protection against infertility in a BALB/c mouse salpingitis model by intranasal immunization with the mouse pneumonitis biovar of Chlamydia trachomatis. Infect. Immun. 62:3354-3362, 1994.
- de la Maza, M. and L.M. de la Maza. A new computer model for estimating the impact of vaccination protocols and its application to the study of Chlamydia trachomatis genital infections. Vaccine. 13:119-127, 1995.
List of Publicatons via PubMed (NIH National Library of Medicine)
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