Byung H. Choi
Professor Emeritus of Neuropathology
    M.D., Severance Union Medical College (Korea), 1953
    Ph.D., Yonsei University (Korea), 1963

UCI Faculty Profile

The research interests of this laboratory are developmental neurobiology dealing with the mechanism of neuronal migration and final positioning, the lineage studies of macroglial and microglial cells in the CNS, ontogenesis of excitatory amino acid receptors in the developing brain, the effects of methylmercury on the developing brain, the protease nexins in development and CNS pathology and studies of Alzheimer's disease.

• Choi BH, Lapham LW: Radial glia in the human fetal cerebrum: A combined Golgi, electron microscopic and immunofluorescent study. Brain Res. 148:295-311, 1978.
  
  
• Choi BH, Lapham LW, Amin-Zaki L, Saleem T: Abnormal neuronal migration, deranged cerebral cortical organization and diffuse white matter astrocytosis of human fetal brain: A major effect of methylmercury poisoning in utero. J. Neuropath. Exp. Neurol. 37:719-733, 1978.
  
  
• Choi BH, Lapham LW: Evolution of Bergmann glia in human fetal cerebellum: A Golgi, immunofluorescent and electron microscopic study. Brain Res. 190:369-383, 1980.
  
• Choi BH: Hematogenous cells in the central nervous system of human embryos and fetuses. J. Comp. Neurol. 196:683-694, 1981.
  
  
• Choi BH: Radial glia of developing human fetal spinal cord: Golgi, immuno-histochemical and electron microscopic study. Dev. Brain Res. 1:249-267, 1981.
  
  
• Choi BH, Kudo M: Abnormal neuronal migration and gliomatosis cerebri in epidermal nevus syndrome. Acta Neuropathol. (Berl) 53:319-325, 1981.
  
  
• Choi BH, Kudo M, Lapham LW: A Golgi and electron microscopic study of cerebellum in methymercury-poisoned neonatal mice. Acta Neuropathol. (Berl) 54:233-237, 1981.
  
  
• Choi BH, Kim RC, Lapham LW: Do radial glia give rise to both astroglial and oligodendroglial cells? Dev. Brain Res. 8:119-130, 1983.
  
  
• Choi BH: Mercury and abnormal fetal brain development. In: Neurobiology of the Trace Elements. Dreosti and Smith (eds) Humana Press. New York 1983, pp. 197-235.
  
  
• Choi BH: Effects of methylmercury on fetal brain. In: Reproductive and Developmental Toxicity of Metals. Clarkson, Nordberg and Sager (eds) Plenum Press. New York, 1983, pp. 473-495.
  
  
• Choi BH, Kim RC: Expression of glial fibrillary acidic protein in immature oligodendroglia. Science. 223:407-495, 1984.
  
• Choi BH, Ruess WR, Kim RC: Disturbances in neuronal migration and laminar cortical organization associated with multicystic encephalopathy in Pena-Shokeir syndrome. Acta Neuropathol. (Berl) 69:177-183, 1986.
  
  
• Choi BH: Glial fibrillary acidic protein in radial glia of early human fetal cerebrum: A light and electron microscopic immunoperoxidase study. J. Neuropathol. Exp. Neurol. 45:408-418, 1986.
  
  
• Choi BH: Myelin-forming oligodendrocytes of developing mouse spinal cord: immunocytochemical and ultrastructural studies. J. Neuropathol. Exp. Neurol. 45:513-524, 1986.
  
  
• Choi BH, Matthias SC: Cortical dysplasia associated with massive ectopia of neurons and glial cells within the subarachoid space. Acta Neuropathol. (Berl) 73:105-109, 1987.
  
  
• Choi BH: Developmental events during the early stages of cerebral cortical neurogenesis in man: A correlative light, electron microscopic, immunohistochemical and Golgi study. Acta Neuropathol. (Berl) 75:441-447, 1988.
  
  
• Peckham NH, Choi BH: Abnormal neuronal distribution within the cerebral cortex after prenatal methylmercury intoxication. Acta Neuropathol (Berl) 76:222-226, 1988.
  
  
• Choi BH: Prenatal gliogenesis in the developing cerebrum of the mouse. Glia. 1:308-316, 1988.
  
  
• Choi BH: The effects of methylmercury on the developing brain. Progress in Neurobiol. 32:447-470, 1989.
  
  
• Van Nostrand WE, Wagner SL, Suzuki M, Choi BH, Farrow JS, Geddes JW, Cotman CW, Cunningham DD: Protease nexin-2, a potent anti-chymotrypsin, shows identity to b-amyloid precursor protein. Nature. 341:546-549, 1989.
  
  
• Suzuki M, Choi BH: The behavior of the extracellular matrix and the basal lamina during the repair of cryogenic injury in the adult rat cerebral cortex. Acta Neuropathologica. 80:355-361.
  
  
• Choi BH, Suzuki M, Kim T, Wagner SL, Cunningham DD: Protease nexin-1: localization in human brain suggests a protective role against extravasated serine proteases. Amer. J. Pathol. 137:741-747, 1990.
  
  
• Choi BH: Effects of methylmercury on neuroepithelial germinal cells in the developing telencephalic vesicles of mice. Acta Neuropathol. 81:359-365, 1991.
  
  
• Suzuki M, Choi BH: Repair and reconstruction of the cortical plate following closed cryogenic injury to the neonatal rat cerebrum. Acta Neuropathol. 82:93-101, 1991.
  
  
• Choi BH, Kim RC, Suzuki M, Choe W: The ventriculus terminalis and filum terminale of human spinal cord. Human Pathol. 23:916-920, 1992.
  
  
• Kim TS, Choi BH, Choe W, Kim RC, Van Nostrand W, Wagner S, Cunningham D: Expression of protease nexin-II in dorsal root ganglia of man: a correlative immunocytochemical and in-situ hybridization study. Mol. Chem. Neuropathol. 16:225-239, 1992.
  
  
• Lee HS, Choi BH: Density and distribution of excitatory amino acid receptors in the developing human fetal brain: A quantitative autoradiographic study. Exper. Neurol. 118:284-290, 1992.
  
  
• Choi, BH: The role of the basement membrane in neurogenesis and repair of injury in the central nervous system. Mic. Res. Tech. 28:193-203, 1994.
  
  
• Yee S, Choi BH: Methylmercury poisoning induces oxidative stress in the mouse brain. Exp. Mol. Pathol. 60:188-196, 1994.
  
  
• Kim P, Choi BH: Selective inhibition of glutamate uptake by mercury in cultured mouse astrocytes. Yonsei Med. J. 36:299-305, 1995.
  
  
• Choi BH, Kim RC, Vaughn PJ, Lau A, Van Nostrand WE, Cotman, CW, Cunningham, DD: Decreases in protease nexins in Alzheimer's disease brain. Neurobiol. Aging. 16:557-562, 1995.
  
  
• Choi, BH: Oxidative stress in Alzheimer's disease. Neurobiol. Aging. 16:675-678, 1995.
  
  
• Yee S, Choi BH: Oxidative stress in neurotoxic effects of methylmercury poisoning. Neurotoxicology. 17:17-26, 1996.
  
  
• Choi BH, Yee S., Robles M: The role of glutathione in methylmercury poisoning . Toxicol. Appl. Pharmacol. 141:357-364, 1996.
  
  
• Choi BH: Role of Radial glia in Neurotoxic Injury. In: The Role of Glia in Neurotoxicity. Aschner and Kimelberg (eds). CRC Press, Inc., Boca Raton, FL, 1996, pp. 47-67.
  
  
• Robles M, Wang N, Kim R, Choi BH: Cytotoxic effects of repin, a principal sesquiterpene lactone of Russian knapweed. J. Neurosci. Res. 47:90-97, 1997.
  
  
• Oak S, Choi BH: The effects of glutathione glycoside in acetaminophen-induced liver cell necrosis Exp. Mol. Pathol. 65:15-24, 1998.
  
  
• Ikeda T, Murata Y, Quilligan EJ, Choi BH, Parer JT, Doi S, Park SD : Physiological and histological changes of brain in near-term fetal lambs exposed to asphyxia by partial umbilical cord occlusion. Am. J. Obst. Gynecol. 178:24-32, 1998.
  
  
• Robles M, Choi BH, Han B, Santa Kruz K, Kim RC: Repin-induced neurotoxicity in rodents. Exp. Neurol. 152:129-136, 1998.
  
  
• Ikeda T, Choi BH, Yee S, Murata Y, Quilligan EJ: Oxidative stress, brain white matter damage and intrauterine asphyxia in fetal lambs. Internat. J. Dev. Neurosci. 17(1):1-14, 1999.

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List of Publicatons via PubMed (NIH National Library of Medicine)