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Research

 

Radiation Biology Research 

Medical Physics Research (To down load the PowerPoint files, click on the cooresponding links) 
  1. Saw C., Yakoob R, Enke CA, Lau TP, Ayyangar, KM. "Immobilization Devices for Intensity Modulated Radiation Therapy (IMRT)" Medical Dosimetry 26 (1):71-77, 2001.
  2. Al-Ghazi MA, Kwon R, Kuo J, Ramsinghani NS, Yakoob R. "The University of California, Irvine Experience with Tomotherapy Using the Peacock System."
    Medical Dosimetry 26 (1): 17-27, 2001.
  3. R. Sanford, H. Chung, M. Al-Ghazi, E. Orlowski III, R. Yakoob "Clinical Implementation of Image-Based Radiation Treatment Planning at UCI Medical Center Department of Radiation Oncology".
  4. R. Sanford, Ph.D., M. Al-Ghazi, Ph.D., H. Chung, B.S., and R. Yakoob, M.S., "Dosimetric Validation of Clinical Serial Tomotherapy Delivery".
  5. M. AL-Ghazi, R. Yakoob, H. Chung, T. Lau and R. Sanford, "Verification Of Accuracy of Treatment Delivery in Serial Tomotherapy".
  6. Robert S. Kwon, M.D., Muthana S.A.L. AL-Ghazi, Ph.D., Jeffrey V. Kuo, M.D., Nilam S. Ramsinghani, M.D., Richard M. Yakoob, M.S. "Dynamic IMRT with Peacock: The University of California, Irvine Experience.

Recent Publications for Radiation Biology 

  1. Redpath JL, Liang D, Taylor TH, Christie C, Elmore E. "The shape of the dose response curve for radiation-induced neoplastic transformation in vitro: Evidence for an adaptive response against neoplastic transformation at low doses of low LET radiation." Radiat Res 156:700-707, 2001.
  2. Elmore E, Luc T-T, Steele VE, Kelloff GJ, Redpath JL. "Comparative tissue-specific toxicities of twenty cancer preventive agents using cultured cells from eight different normal human epithelia." In Vitro & Molecular Toxicol 14:191-207, 2001.
  3. JL Redpath, D Liang, TH Taylor, C Christie, E Elmore. "The shape of the dose-response curve for radiation-induced neoplastic transformation : Evidence for an adaptive response against neoplastic transformation at low doses of low LET radiation." Radiat Res 156 : 700-707, 2001.
  4. E Elmore, T-T Luc, VE Steele, GJ Kelloff, JL Redpath. "Comparative Tissue-Specific Toxicities of twenty cancer preventive agents using cultured cells from eight different normal human epithelia." In Vitro Mol Toxicol 14(3): 191-207, 2001.
  5. E. Elmore, C. Sun, H-R. Li, G.P. Wyatt, J.A. Buckmeier, V.E. Steele, G.J. Kelloff and J.L.Redpath, "In vitro chempopreventive efficacy screening using human keratinocytes and the in vivo data correlation", Anticancer Research, 19, 909-918 (1999).
  6. E. Elmore, T-T. Luc, H-R. Li J.A. Buckmeier, V.E. Steele, G. J. Kelloff, and J.L. Redpath, "Correlation of chemopreventive efficacy data form the human epidermal cell assay with in vivo data", Anticancer Research, 20, 27-32 (2000).
  7. T. Suzuki, A. Iwazaki, H. Katagari, Y. Oka, J.L. Redpath, E.J. Stanbridge and T. Kitigawa, "Enhanced expression of glucose transporter GLUT3 in tumorigenic HeLa cell hybrids associated with tumor suppression dysfunction", Eur. J. Biochem., 262, 534-540 (1999).
  8. J.N. DeSimone, H. Dolezalova, J.L. Redpath and E.J Stanbridge, "Permanent cell cycle arrest in irradiated human diploid skin fibroblasts: The role of nutrient deprivation", Radiation Research, 153, 131-143 (2000).
  9. E. Elmore, T-T. Luc, V.E. Steele, G.J. Kelloff and J.L. Redpath, "The human epithelial cell cytotoxicity assay for determining tissue specific toxicity", Methods in Cell Science, 22, 17-24 (2000).
  10. H. Tsujimoto, S. Nishikawa, J.L. Redpath and E.J. Stanbridge, "Differential gene expression in tumorigenic and non-tumorigenic HeLa x normal human fibroblast cell lines", Molecular Carcinogenesis, 26, 298-304 (1999).
  11. E. Srivatsan, U. Bengsston, P. Manickam, P. Benyamini, S.C. Chandrasekhrappa, C. Sun, E.J. Stanbridge and J.L. Redpath, "Interstitial deletion of chromosome 11q13 sequences in HeLa cells", Genes, Chromosomes and Cancer, in press
  12. F. Yildiz, R. Perez and J.L. Redpath, "Paclitaxel exposure time determines the nature of the interaction with radiation in HeLa cells: the role of apoptosis", Eur. J Cancer, in press.
  13. E.S. Srivatasan, M. Mendonca, R.A. Jedusan, U. Bengtsson, R. Chakrabati, P. Benyamini, C. Sun, E.J. Stanbridge, and J.L. Redpath, "Homozygous deletion of chromosome 11q13 sequences in HeLa cells", Cancer Research, submitted.

Abstracts and Presentations

  1. M. Wakabayashi, J. DeSimone, E.J. Stanbridge and J.L. Redpath, "Factors influencing cell cycle progression following radiation damage", Proceedings of the Eleventh International Congress of Radiation Research, Dublin. Ireland, July 18-23, 1999, Radiation Research, Volume 1,Abstracts,AbstractCCE37,p.199.
  2. D. Bettega, P. Calozari, S. Genchi, P. Massariello, S. Orsini and J.L. Redpath, "Biological effectiveness of solar UV radiation", Proceedings of the Eleventh International Congress of Radiation Research, Dublin. Ireland, July 18-23, 1999, Radiation Research, Volume 1,Abstracts,AbstractES4,p.243.
  3. J.L. Redpath, "Genetic and epigenetic mechanisms in radiation-induced neoplastic transformation of human hybrid cells in culture", Proceedings of the 27th Annula Meeting of the American Society for Photobiology, July 10-15, 1999.
  4. J.L. Redpath, "Induction of an adaptive response aganst neoplastic transformation in vitro by low dose gamma-irradiation", Department of Energy, Low Dose Radiation Research Meeting, Nov. 10-12, 1999, Bethesda, Maryland.
  5. E. Elmore, " Analysis of DFMO induced changes in cancer gene expression in human colon polyp cell lines using microarray analysis". Presented at Chao Family Comprehensive Cancer Center Conference, Palm Springs, CA, October, 1999
  6. E. Elmore, T-T. Luc, V.E. Steele, G.J. Kelloff, and J.L. Redpath. " Determination of tissue specific drug toxicity using epithelial cells from eight different human tissues". Annual Meeting of Society of Toxicology, Philadelphia, March 19-23, 2000, in The Toxicologist 54:408, 2000
  7. E. Elmore, R.A. Lubet, J.L. Redpath, G.J. Kelloff, and V.E. Steele. "Analysis of DFMO induced changes in cancer related gene expression in two pre-cancerous human colon polyp cell lines using RNA microarrays". Proc. Am. Assoc. Cancer Res. 11:664, 2000
  8. E. Elmore, R.A. Lubet, J.L. Redpath, G.J. Kelloff, and V.E. Steele. RNA Microarray Analysis of DFMO Induced Changes in Cancer-Related Gene Expression in Two Pre-cancerous Human Colon Polyp Cell Lines. 2000 World Congress on In Vitro Biology, San Diego, June 10-15, in In Vitro Cellular and Devel. Biol. 36:49A, 2000
  9. E. Elmore, The use of normal human epithelial cells for determining cancer prevention efficacy and toxicity. To be presented at the Seventh International Conference on Mechanisms of Antimutagenesis and Anticarcinogenesis, September, 2000
  10. KM Ignatoski, AJ Lapointe, EH Radany, SP Ethier. erbB-2 overexpression in human mammary epithelial cells confers growth factor independence. Endocrinology 140:3615-22, 1999
  11. EH Radany, KJ Dornfeld, RJ Sanderson, MK Savage, A Majumdar, MM Seidman, DW Mosbaugh. Increased spontaneous mutation frequency in human cells expressing the phage PBS2-encoded inhibitor of uracil-DNA glycosylase. Mutation Research DNA Repair 461(1): 41-58 in press, 2000
  12. EH Radany. Interaction with a binding protein is the likely cause of accelerated cytosine deamination at specific, non-methylated DNA sequence motifs in mammalian cells. Gordon Research Conference, "Mutagenesis and Carcinogenesis", Ventura, CA February 27-March 3, 2000
  13. KP Huynh, M Abo-Hebeish, EH Radany The YnjG/EcoGene14009/b1759 protein is a candidate novel "NUDIX" (MutT-like) nucleotide tripphosphatase anti-mutator in E. coli. Gordon Research Conference, "Mutagenesis and Carcinogenesis", Ventura, CA February 27-March 3, 2000
  14. EH Radany. Radiation Therapy of Malignant Brain Tumors. Southern California Society of Radiation Therapists. Orange, CA, March 18, 2000.
  15. EH Radany. Transgenic Mice: Pros and Cons as Models of Human Disease. 47th annual meeting of the Radiation Research Society, Albuquerque, NM, May 2, 2000

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