Professor and Vice-Chair, Academic Affairs  

Education:  

B.S.:University of Newcastle-upon-Tyne, Chemistry & Physics (1965)  

Ph.D.: University of Newcastle-upon-Tyne, Radiation Chemistry (1968)  

Areas of Interest:  

Dr. Redpath's research interests are principally basic laboratory studies on the effects of radiation on human cells in vitro at the cellular and molecular level. One major interest is in mechanisms underlying the radiation-induction of cancer. Current research is addressing several questions. One is on the role of p53-dependent and -independent cell cycle checkpoints in determining the genetic stability of the progeny of irradiated cells. Another is on the contribution of epigenetic mechanisms to the delayed expression of radiation damage. Yet another is the possible induction by low doses of radiation (1 cGy) of an adaptive response against the spontaneous neoplastic transformation. These studies are supported by grants from NIH/NCI and DOE. Together with Dr. Elmore, Dr. Redpath is also developing and utilizing human epithelial cell-based assays to examine the efficacy of candidate chemopreventive agents. This work is supportedthrough c ontracts from NIH/NCI.  

Teaching Involvement:  

Dr. Redpath teaches a comprehensive course on radiobiology to radiation oncology residents. In addition, Dr. Redpath teaches selected topics in radiobiology to residents in diagnostic radiology, otolaryngology and fellows in gynecologic oncology. At the graduate level Dr. Redpath gives two lectures on radiation toxicity to students in the Environmental Toxicology Graduate Program. At the undergraduate level Dr. Redpath supervises undergraduate research projects (Bio Sci 199).  

Society Membership:  

Radiation Research Society  

ASTRO  

American Association for Cancer Research  

Association for Radiation Research (UK)  

Participation in Study Group:  

Dr. Redpath is part of a large international study group sponsored by DOE which is examining the biological effects of low doses of radiation and their relevance to clean-up of hazardous waste sites.

Publications  

(1) J.N. DeSimone, H. Dolezavola, J.L. Redpath, and E.J. Stanbridge, "Prolonged cell cycle arrest in irradiated human diploid skin fibroblasts: The role of nutrient deprivation", Radiat. Res., 153, 131-143, 2000.  

(2) E. Elmore, C. Sun, H-R. Li, G.P. Wyatt, J.A. Buckmeier, G.J. Kelloff, V.E. Steele and J.L. Redpath, In vitro chemopreventive efficacy screening using human keratinocytes and the in vivo data correlation. Anticancer Res., 19, 909-918, 1999  

(3) H. Tsujimoto, S. Nishizuka, J.L. Redpath, and E.J. Stanbridge, "Differential gene expression in tumorigenic and non-tumorigenic HeLa x normal human fibroblast human hybrid cells", Mol. Carcinogenesis, 26, 298-304, 1999.  

(4) T. Suzuki, A. Iwazaki, H. Katagari, Y. Oka, J.L. Redpath, E.J. Stanbridge and T. Kitigawa, "Enhanced expression of glucose transporter GLUT3 in tumorigenic HeLa cell hybrids associated with tumor suppressot dysfunction", Eur. J. Biochem., 262, 534-540, 1999.  

(5) G.H. Ehring, R.J. Antoniono and J.L. Redpath, Gap junction expression following UVC-induced neoplastic transformation in human hybrid cell lines, Carcinogenesis, 19, 2085-2093, 1998.  

(6) H.L. de Fiejter-Rupp, T. Hayashi, G.H. Kalimi, P. Edwars, J.L. Redpath, C.C. Chang, E.J. Stanbridge and J.E. Trosko, Restored gap junctional communication in non-tumorigenic HeLa-normal human fibroblast hybrids, Carcinogenesis, 19, 747-754, 1998.  

(7) J.L. Redpath and R.J. Antonio, Induction of an adaptive respinse against spontaneous neoplastic transformation invitro by low dose gamma-irradiation, Radiat. Res., 149, 517-520, 1998. (8) M.S. Mendonca, K. Howard, C.L. Fasching, D.L. Farrington, L.A. Desmond, E.J. Stanbridge and J.L Redpath, Loss of suppressor loci on chromosomes 11 and 14 may be required for radiation-induced neoplastic transformation of human cell hybrides, Radiat. Res., 149, 246-255, 1998.

Assistant Professor