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FACULTY

Adolescent Medicine
Allergy & Immunology
Cardiology
Critical Care/PICU
Endocrinology
General Pediatrics
Hematology/Oncology
Human Genetics & Metabolism
Infectious Disease
Neonatal/Perinatal Medicine
Nephrology
Neurology
Tallie Z. Baram, M.D., Ph.D.
Shelley Bose, MBBS, MRCP
Joseph H. Donnelly, M.D.
Pauline A. Filipek, M.D.
Glenn W. Fowler, M.D.
Richard Haier, Ph.D.
Ira Lott, M.D.
Paul E. Touchette, Ed.D.
Anne Tournay, M.D.

Pulmonology
Child Development Center
General Clinical Research Center

• Position:
• Professor of Pediatrics
• Chief of Pediatric Neurology Division
• Professor of Neurology
• Associate Dean of Clinical Neurosciences
• Director of Neurosciences Development, UCI Health Systems


• EDUCATION


• Medical School Education:
• Ohio State University College of Medicine with honors


• Internship & Residency:
• Intern, Children's Service - Massachusetts General Hospital, Boston, MA
• Second Assistant Resident, Children's Service - Massachusetts General Hospital
• Junior Assistant Resident, Neurology Service - Massachusetts General Hospital
• Assistant Resident in Neuropathology, Chief Resident in Child Neurology - Massachusetts General Hospital
• Senior Resident in Neurology (Child) - Massachusetts General Hospital


• Fellowships:
• Clinical Associate in Pediatric Neurology - National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD
• Research Fellow in Neurology - Harvard Medical School, Boston, MA


• HONORS & AWARDS


• Honors:
• Alpha Omega Alpha
• Appointed Examiner, American Board of Psychiatry and Neurology, Section on Child Neurology
• Elected Secretary-Treasurer, Child Neurology Society
• Elected Councilor, Professors of Child Neurology
• Elected to Council, Western Society for Pediatric Research
• Appointed to Section on Neurology/Child Neurology, United States Pharmacopeia, Washington, D.C.
• Elected President, Professors of Child Neurology
• Member, Neuroscience Review Committee, Western Society for Pediatric Research
• Invited Member, NIH Review Panels
• Marquis Who's Who in America, Who's Who in the World, Who's Who in Science and Engineering
• Woodward and White's, "Best Doctors in America", Pacific Region
• Specialist Site Reviewer, Accreditation Council on Graduate Medical Education
• Appointed, Director, Mental Retardation Developmental Disabilities Research Center (NICHD), University of California, Irvine
• Appointed, Director, Science Advisory Board, National Down Syndrome Society


• Awards:
• Clinical and Research Fellowship Award in Pediatric Neurology, NINDS, National Institutes of Health
• Career Development Award, Joseph P. Kennedy Jr. Foundation
• Recipient of the Waisman Memorial Lectureship, Waisman Mental Retardation Research Center, University of Wisconsin
• Recipient of National Down Syndrome Society Research Award
• Recipient, Christian Puschel Memorial Research Award, National Down Syndrome Congress, Anaheim, CA
• Recipient, Spotlight Award for outstanding service to people with developmental disabilities as a health care provider, Regional Center of Orange County


• MEMBERSHIPS & AFFILIATIONS


• Board Certifications:
• American Board of Pediatrics
• American Board of Psychiatry and Neurology with Special Competence in Child Neurology


• Professional Societies:
• American Academy of Neurology
• American Academy of Pediatrics
• Child Neurology Society
• International Child Neurology Society
• California Medical Association
• Western Society for Pediatric Research
• Orange County Societies of Neurology and Pediatrics
• Professors of Child Neurology (elected)
• Society for Pediatric Research (elected)
• American Pediatric Society (elected)
• American Academy on Mental Retardation (elected)


• SELECTED PUBLICATIONS:


• 1. Lott IT, Wheeldon JA, Levy HL, Speech and Histidinemia: Methodology and evaluation of four cases. Develop Med and Child Neurol. 1970;12:596 603


• 2. Rapport JL, Lott IT, Alexander DF, Abramson AV, Letter: Urinary nor adrenaline and playroom behavior in hyperactive boys. Lancet. 1970;2:1141.


• 3. Rapport JL, Abramson A, Alexander DF, Lott IT: Playroom observation of hyperactive children on medication. J Am Acad Child Psych. 1971;10:524 534.


• 4. Lott IT, Erickson AM, Levy HL: Dietary treatment of an infant with isovaleric acidemia. Pediatrics. 1972;49:616 618.


• 5. Lott IT, Murphy DL, Chase TN: Down syndrome: Central monoamine turnover in patients with diminished platelet serotonin. Neurol. 1972;22:967 972.


• 6. Lott IT, Chase TN, Murphy DL: Down syndrome: Transport, storage, and serotonin in blood platelets. Pediatric Res. 1972;6:730 735.


• 7. Lott IT, Klein DC, Quarles RB: Biosynthesis and release of glycoproteins by pineal gland in vitro. Biochem Biophys Acta. 1972;264:144 151.


• 8. Levy HL, Erickson AM, Lott IT, Kurtz DJ: Isovaleric acidemia: Results of family study and dietary treatment. Pediatrics. 1973;52:83 94.


• 9. Lott IT, Janowska S, Schwartz D, Dipaolo R, Kanfer JN: Copper metabolism in steely hair syndrome. N Eng J Med. 1975;292:197 199.


• 10. Lott IT, DiPaolo R, Kanfer JN: Letter: Steely hair syndrome and copper. N Eng J Med 1975;292:1193 1194.


• 11. Lott IT, Dulaney JT, Milunsky A, Hoefnagel D, Moser HW: Apparent biochemical homozygosity in two obligatory heterozygotes for metachromatic leukodystrophy. J Ped. 1976;89:438 440.


• 12. Kistler PJ, Lott IT, Kolodny EH, Friedman RB, Nersasian R, Schnur J, Mihm MC, Dvorak AM, Dickersin R: Mannosidosis: New clinical presentation, enzyme studies, and carbohydrate analysis. Arch Neurol. 1976;34:45 51.


• 13. Williams RS, Lott IT, Ferrante RJ, Caviness VS: The cellular pathology of late infantile neuronalceroid lipofuscinosis: A Golgi EM study. Arch Neurol. 1977;34:298 305.


• 14. Lott IT, Dulaney JT: Sulfatide excretion in metachromatic leukodystrophy (Letter). Am J Med Genet. 1978;30:228.


• 15. Lott IT, Coulombe T, DiPaolo R, Richardson EP: Vitamin B 6 dependent seizures. Pathology and chemical findings in brain. Neurol. 1978;28:47 54.


• 16. Williams RS, Marshall PC, Lott IT, Caviness VS: The cellular pathology of Menkes' steely hair syndrome. Neurol. 1978;28:575 583.


• 17. Lott IT, DiPaolo R, Raghavan SS, Clopath P, Milunsky A, Robertson WC Jr, Kanfer JN: Abnormal copper metabolism in Menkes' steely hair syndrome. Pediatr Res. 1979;13:845 850.


• 18. Lott IT, Williams RS, Schnur JA, Hier DB: Familial amentia, unusual ventricular calcifications, and increased cerebrospinal fluid protein. Neurol. 1979;29:1571-1577.


• 19. Mathis RK, Watkins JB, Szczepanik Van Leeuween P, Lott IT: Liver in the cerebro hepato renal syndrome, defective bile acid synthesis and abnormal mitochondria. Gastroenterol. 1980;79:1311 1317.


• 20. Dickersin GR, Lott IT, Kolodny EH, Dvorak AM: A light and electron microscopic study of mannosidosis. Hum Path. 1980;11:245 246.


• 21. Marholin D II, Luiselli JK, Robinson M, Lott IT: Response contingent taste aversion in treating chronic ruminative vomiting of institutionalized profoundly retarded children. J Men Defic Res. 1980;24:470 456.


• 22. Lott IT and Daniel PF: Serum and urinary trisaccharides in mannosidosis. Neurol. 1981;31:1159 1162


• 23. Daniel PF, DeFeudis DF, Lott IT: Mannosidosis: Isolation and comparison of mannose containing oligosaccharides from gingiva and urine. Eur J Biochem. 1981;141: 235 237.


• 24. Daniel PF, DeFeudis DF, Lott IT, McCluer RH: Quantitative microanalysis of oligosaccharides by high performance liquid chromatography. Carbohydrate Res. 1981;97:161 180.


• 25. Lott IT, Lai F: Dementia in Down syndrome observations in a neurology clinic, Applied Res Ment Retard. 1982;3:232 239.


• 26. Halperin JJ, Landis DMD, Lott IT, Ment L: Neuroaxonal dystrophy and Down syndrome. Arch Neurol. 1982;39:587 591


• 27. Lott IT: Down syndrome, aging and Alzheimer's disease: A clinical review. Annals NY Acad Sci. 1982;396:15 27.


• 28. Touchette PE and Lott IT: "Errorless" elimination of severe chronic self mutilative behavior. Behavior Analysis, 1982;11:189 192.


• 29. Press OWE, Fingert H, Dickersin GR, Lott IT: Pancytopenia in mannosidosis, Arch Int Med. 1983;143:1266 1269.


• 30. Lott IT, Bocian M, Pribram HW, Leitner M: Fetal hydrocephalus and ear anomalies associated with maternal use of isotretinoin. J Pediatr. 1984;105:597 600.


• 31. Halperin JJ, Landis DM, Weinstein L, Lott IT, Kolodny EH: Communicating hydrocephalus and lysozomal inclusions in mannosidosis. Arch Neurol. 1984;41:777 779.


• 32. Towne BH, Lott IT, Hicks DA, Healey T: Long term follow-up of infants and children treated with extra-corporeal membrane oxygenation (ECMO): A preliminary report. J Pediatr Surg. 1985;20:410 414.


• 33. Lammer EM, Chen DT, Hoar RM, Lott IT, et al: Retinoic acid embryopathy. New Eng J Med. 1985;313:837 841.


• 34. Geddes JW, Monaghan DT, Cotman CW, Lott IT, et al: Plasticity of hippocampal circuitry in Alzheimer's disease. Science. 1985;230:1179 1181.


• 35. Lott IT, McPherson DL: Start cerebral cortical contributions to sensory evoked potentials. Electroenceph and Clin Neurophysiol. 1986;64:218:223.


• 36. Geddes JW, Chui HC, Cooper SM, Lott IT, Cotman CW: Density and Distribution of NMDA receptors in the human hippocampus in Alzheimer's disease. Brain Res. 1986;399:156 161.


• 37. Smith Thomas L, Lott IT, Bronner Fraser M: Effects of isotretinoin on the behavior of neural crest cells in vitro. Develop Biol. 1987;123(1):276 281.


• 38. Rauch R, Friloux L, Lott IT: Cavitary lesions in the brain with Hurler Scheie as shown by MR imaging: Case report. Amer Jour of Neuroradiol. Sept suppl:1, 1989.


• 39. Lott IT, Starr A, McPherson D, Johnson D, Towne B: Long term neurophysiological measures following ECMO. J Peds. 1990;116(3):343 349.


• 40. Sullivan R, Taborsky Barba, Mendoza R, Itano A, Leon M, Cotman, Payne T, Lott IT: Olfactory classical conditioning in neonates. Pediatr. 1990;87(4):511 518.


• 41. Epstein CJ, Korenberg J, Lott IT, et al: Protocols to Establish Genotype-Phenotype Correlations in Down Syndrome. Am J Hum Genet 1991;49:207-235.


• 42. Siegel BV, Asarnow R, Tanguay P, Call J, Lott IT, et al: Regional cerebral glucose metabolism and attention in adults with a history of childhood autism. J of Neuropsychiatry and Clin Neurosc. 1992;4(4):406-14.


• 43. Lott IT, Lottenberg S, Nyhan W, Buchsbaum M: Cerebral metabolic change after treatment in biotinidase deficiency. J Inher Metab Dis. 1993;16:399-407.


• 44. Sandman C, Hetrick W, Taylor D, Touchette P, Lott IT, Barron J, Crinella F, Martinazzi V: Naltrexone reduces self injury and improves learning. J Clinical and Experimental Pharm. 1993;1(1-4):242-258.


• 45. Kesslak JP, Nagata SF, Lott IT, Nalcioglu O: Magnetic resonance imaging analysis of age related changes in the brains of individuals with Down's syndrome. Neurology. 1994;44:1039-1045.


• 46. Nelson LD, Lott IT, Touchette PE, Satz P, D'Elia L: Detection of Alzheimer's Disease in individuals with Down's syndrome: Possible relevance of depression. Amer J Ment Ret. 1995;99:616-22.


• 47. Emerson J, Chen PC, Shankle WR, Greensite FS, Eldon LF, Lott IT, Orhan N: Cortical CSF volume fluctuations by MRI in brain aging, dementia and hydrocephalus. Neuro Report. 1994;5:1699-1704.


• 48. Haier RJ, Chueh D, Touchette P, Lott IT, MacMillan D, Sandman C, LaCasse L, Friedman G, Sosa E: Brain size and cerebral glucose metabolic rate in non-specific mental retardation and Down syndrome. Intelligence. 1995;20(2):191-210.


• 49. Roth GM, Sun B, Greensite FS, Lott IT, Dietrich RB: Premature aging in persons with Down syndrome: MR findings. American Journal of Neuroradiology. 1996;17:1283-1289.


• 50. Azizeh BY, Head E, Ibrahim MA, Torp R, Tenner AJ, Kim RC, Lott IT, Cotman CW: Molecular dating of senile plaques in aged Down’s syndrome and canine brains. Experimental Neurology. 2000; 163:111-122.


• 51. Nelson LD, Orme D, Osann K, Lott IT: Neurological changes and emotional functioning in adults with Down syndrome. J Intell Dis Research, 2001; 45:450-456.


• 52. Howerton K, Fernandez G, Touchette PE, Gurbani S, Sandman CA, Ashurst J, Mahnovski N, Downing A, Lott IT: Interdisciplinary team consultation on the appropriateness of psychotropic medications: Approach and outcomes in community based individuals with developmental disabilities. Ment Health Aspects Dev Disabil 2002; 5:78-86.


• 53. Head E, Garzon-Rodriguez W, Johnson JH, Lott IT, Cotman CW, Glabe C: Oxidation of Aß and plaque biogenesis in Alzheimer's disease and Down syndrome. Neurobiology of Disease, 2001; 8:792-806.


• 54. Lott IT, Head E: Down syndrome and Alzheimer's disease: A link between development and aging. Mental Retardation Developmental Disabilities Research Reviews; 2001; 7:172-178.


• 55. Lott IT: Overview: Progressive Neurological Disorders in Mental Retardation and Developmental Disabilities. Mental Retardation and Developmental Disabilities Research Reviews. 2001; 7:151-152.


• 56. Lott IT, Osann K, Doran E, Nelson LD: Down syndrome and Alzheimer disease: Response to Donepezil. Arch Neurol; 2002; 59:1133-1136.


• 57. Head E, Azizeh BY, Lott IT, Tenner AJ, Cotman CW, Cribbs DH: Complement association with neurons and b-Amyloid deposition in the brains of aged individuals with Down syndrome. Neurology of Disease. 2001; 8:252-265.


• 58. Head E, Lott IT, Cribbs DH, Cotman CW, Rohn TT: ß-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome. Neuroscience Letters. 2002; 330:99-103.


• 59. Head E, Lott IT, Hof PR, Bouras C, Su HJ, Kim R, Haier R, Cotman CW: Parallel compensatory and pathological events associated with tau pathology in middle aged individuals with Down Syndrome. Journal of Neuropathology and Experimental Neurology, 2003; 62:917-926.


• 60. Nelson L, Johnson JK, Freedman M, Lott I, Groot J, Chang M, Milgram NW, Head E: Learning and Memory as a Function of Age in Down syndrome; A Study Using Animal-Based Tasks. Submitted.


• 61. Haier RJ, Alkire MT, White NS, Uncapher MR, Head E, Lott IT, Cotman CW: Temporal cortex hypermetabolism in Down syndrome prior to the onset of dementia. Neurology, 2003; 61:1673-1679.


• 62. Lott IT, McGregor M, Engelman L, Touchette P, Tournay A, Sandman C, Fernandez G, Plon L, Walsh D: Longitudinal prescribing patterns for psychoactive medications in community-based individuals with developmental disabilities: Utilization of pharmacy records. Journal of Intellectual Disability Research, 2004; 48:563-571.


• 63. Lott IT, Head E: Alzheimer disease and Down syndrome: Factors in pathogenesis. Neurobiology of Aging, 2005; 26:383-389.


• 64. Nelson L, Johnson JK, Freedman M, Lott IT, Groot, J, Chang M, Milgram W, Head E: Learning and memory as a function of age in Down syndrome: A study using animal-based tasks. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2005; 29:443-453.


• 65. Lott IT, Head E, Busciglio J: Beta-amyloid, oxidative stress and Down syndrome: Invited review; 100th Anniversary of Alois Alzheimer, Current Alzheimer Research (in press).


• 66. Walsh DM, Finwall J, McGregor M, Fernandez G, Lott IT, Touchette PE, Sandman CA: Rapid assessment of severe cognitive impairment in individuals with developmental disabilities. Journal of Intellectual Disabilities Research (in press).


• 67. Lott IT, Doran E, Walsh D, Hill MA: Telemedicine in the diagnosis of dementia in Down syndrome: Implications for Alzheimer disease. (In Press, Alzheimer Disease and Associated Disorders, 2006).


• 68. Doran E, Osann K, Spence MA, Flodman P, Filipek P, Modahl C, Lott IT: Behavior in Children with a Dual Diagnosis of Down Syndrome and Autistic Disorder. (Under review, Am J Ment Retard, 2005).


• 69. Nistor M, Don M, Parekh M, Sarsoza F, Goodus M, Lopez GE, Kawas C, Leverenz J, Doran E, Lott IT, Hill M, Head E: Alpha-and Beta-Secretase Activity as a Function of Age and Beta-Amyloid in Down Syndrome and Normal Aging Brain. (Under review, Neurobiology of Aging, 2005).


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