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Academic Address:
University of California, Irvine
314 Sprague Hall
ZC 7700
Irvine, CA 92697
Email:
huangts@uci.edu
Taosheng Huang, M.D., Ph.D.
- Faculty Profile
- Position:
- Assistant Professor of Pediatrics
- - Human Genetics Division & Metabolism
- Research Geneticist, Mitochondrial and Molecular Medicine
- EDUCATION
- Graduate Education:
- Ph.D., Mount Sinai Medical School, New York, NY
- Medical School Education:
- M.D., Fujian Medical College, Fuzhou, Fujian
- Residency:
- Children's Medical Center, Georgetown University Pediatrics
- Fellowship:
- Clinical Fellow in Genetics & Metabolism, Harvard Medical School
- HONORS & AWARDS
- Junior Physician-Scientist Award, UC Irvine, 2004
- Clinical Associate Physician Award, National Health Institute, 1999-2004
- Second Place Research Award, UC Irvine, 2003
- Fellowship Training Grant, National Health Institute/Harvard Medical School, 1996
- Resident Research Award, Georgetown University Hospital, 1996
- Third Place, SCBA Poster Competition 1990.
- MEMBERSHIPS & AFFILIATIONS
- Board Certifications:
- American Board of Pediatrics
- American Board of Clinical Genetics
- Sub-board of Clinical Molecular Genetics
- Professional Societies:
- American College of Medical Genetics
- American Society of Human Genetics
- American Association for Advancement of Science
- RESEARCH
- The primary interests of our lab is to study the molecular basis of genetic syndromes,
and apply discoveries from genetic syndromes to common diseases. Currently, our lab is focusing on the
following areas. For more information please visit: www.ucihs.uci.edu/pediatrics/drhuang/
- 1. To study the role of TBX3 in breast cancer. TBX3 is also a T-box transcription factor. Mutation of TBX3 causes Ulnar-Mammary syndrome characterized by hypoplasia and absence of the mammary gland.
Oveexpression of TBX3 plays an important role in breast cancer. To study the role of TBX3 in breast cancer, we are working on an animal model, and analyzed TBX3 expression in human breast cancer tissue. By working with animal and breast cancer tissue, our research aims to optimize the clinical relevance of our work
- 2. To identify the disease-causing gene associated with noncompaction of the ventricular myocardium (spongy heart), we are studying a family with balanced translocation with this condition, and are also performing a linkage study and search for mutations of the candidate gene with this disease.
- 3. The intracellular pathway to study TBX5. TBX5 is a T-box transcription factor. Mutations of TBX5 cause Holt-Oram syndrome characterized by congenital heart diseases and limb anomalies. By studying the intracellular network of TBX5, including the upstream transcription factor that controls TBX5 expression cofactor that interacts with TBX5 and downstream target whose genetic regulation is dependent on TBX5. We anticipate identifying many genes associated with congenital heart disease, a most common malformation in humans, and contribute significantly to the mobility and mortality in pediatric populations.
- 4. The Genetic basis of optic atrophy. We are performing linkage analysis and candidate gene mutation analysis to elucidate the genetic cause of this condition. The animal models will be used fro stem cell therapy.
- I am the director of the cardiovascular genetics clinic. My clinical research is on the genetic
syndromes with cardiac malformations and metabolic disease. In addition, I am the associate director of MitoMed
Molecular Diagnostic lab.
For more information please visit: mitomap.bio.uci.edu/mitomed/staff.html
- SELECTED PUBLICATIONS
- 1. Huang T, Palese P, and Krystal M. Determination of influenza virus proteins required for genome replication. Journal of Virology 64:5669-5673. 1990
- 2. Chu Y, Huang T, and Hsu MT. P1 nuclease defines a subpopulation of active SV40 chromatin-- a new nuclease hypersensitivity assay. Nucleic Acid Research 18:3705-3711. 1989
- 3. Huang T, and Hsu MT. Inhibition of DNA replication of adenovirus type 5 and Simian virus 40 by tunicamycin. Virology 182:889-893. 1991
- 4. Park KH, Huang T, Correia FF, and Krystal M. Rescue of a foreign gene by Sendai virus. Proceeding of the National Academy Sciences of USA 88:5537-5541. 1991
- 5. Huang T, Pavloic J, Staeheli P, and Krystal M. Overexpression of the influenza polymerase protein can titrate out inhibition by the murine Mx1 protein. Journal of Virology 66:4154-4160. 1992
- 6. Taosheng Huang, Ellen Elias, John B Mulliken, Daniel J Kirse and Lewis B Holmes. A new syndrome: cardiac defects, Laryngeal anomalies, preaxial polydactyly, and colonic aganglionosis in sibs. Genetics in Medicine, 1(3):104-108, 1999 (Collected by Possum Database and OMIN)
- 7. Craig T Basson, Taosheng Huang, Robert Lin, David R Bachinsky, Stanislawa Weremowicz, Alicia Vaglio, Rina Bruzzone, Roberto Quadrelli, Margherita Lerone, Giovanni Romeo, Margherita Silengo, Cynthia C Morton, Christoph W Muller, JG Seidman, Christine E Seidman, Different TBX5 interactions in heart and limb defined by Holt-Oram syndrome. Proceedings of the National Academy Sciences of the USA, 96:2919-2924, 1999
- 8. Taosheng Huang, Wenxue Yang, Alexandre Pereira, Vivian E Shih. Cloning and characterization of a putative human 2-hydroxylacid dehydrogenase, Biophysica Biochemica Research Communication, 268:298-301. 2000
- 9. Taosheng Huang, Angela E. Lin, Gerry Cox, Wendy L. Golden, Mitsuhiro Kamisago, Gerald L. Feldman, Stefan Vermeulen, Moog Ute, Connie Schrander-Stumpel: Variable Cardiac Phenotypes in Chromosome 4q- Syndrome with dHAND Deletion, Genetics in Medicine, 4(6) 464-467, 2002
- 10. Taosheng Huang & Mark Korson, Celeste Krauss, Lewis B. Holmes: A New Genetic Syndrome: Four Cases with Encephalocele, triphalangeal thumb, American Journal of Medical Genetics 111:178-181, 2002 (Collected by London Dysmorphology Database)
- 11. Taosheng Huang: Current advances in Holt-Oram syndrome, Curr Opin Pediatr. 14(6):691-5. 2002
- 12. Taosheng Huang, James E Lock, Audrey C Marshall, Craig Basson, J.G. Seidman, Christine E. Seidman. Causes of Clinical Diversity in TBX5 Mutations Cold Spring Harbor Quantitative Biology Symposium, LXVII 115-120, 2003
- 13. Helen M. Lyon, Lewis B Holmes and Taosheng Huang Multiple congenital anomalies associated with in utero exposure phynotoin support hypoxic ischemic mechanisms Birth Defect Research (Part A) 67:993-996, 2003
- 14. Drapkin RI, Genest DR, Holmes LB, Huang T, Vargas SO. Unilateral transverse arm defect with subterminal digital nubbins. Pediatrics Developmental Pathology 6(4): 348-354, 2003.
- 15. Guifeng Sun Lisa E Lewis, Xu Huang, Quang Nguyen, Christopher Price, Taosheng Huang: TBX5, a gene mutated in Holt-Oram syndrome, is regulated through a GC box and T-box binding elements (TBEs), Journal of Cellular Biochemistry, 2004; 92(1):189-99
- 16. Mike Zaragoza, Lisa E. Lewis, Guifeng Sun, Eric Wang, Ling Li, Ilham Said-Salman, Laura Feucht, Taosheng Huang: Identification of the TBX5 Transactivating Domain And the Nuclear Localization Signal, Gene, 2004, 330:9-18
- 17. Weiwei Fan, Xu Huang, Chira Chen, Joe Gray and Taosheng Huang: TBX3 and TBX3+2a are Functionally Distinctive in Inhibition of Senescence and are Overexpressed in a Subset of Breast Cancer Cell Lines, Cancer Research, 2004, 64(15):5132-9
- 18. Taosheng Haung, Ming Qi. Report − 21st century medical genetic and genomic medicine in China, Journal of Zhejian University Science.
- 19. Taosheng Huang, Whang JD, Kimonis V: Sex-influenced autosomal dominant optic atrophy is caused by mutations of IVS9 +2A>G in the OPA1 gene. Genetics in Medicine. 2006, 8(1):59.
- 20. Avetis Boyadjian, Xianhe Xie, Taosheng Huang Mutation Analysis of TBX5 in Families with Holt-Oram Syndrome, submitted
- 21. Hongfei Pan, Guifang Long, Qiang Li, Yanni Feng, Zhiying Lei, Hongwei Wei, Yueyan Huang, Jinghong Huang, Na Lin, Qunqing Xu, Shaiyong Ling, Xiajing Chen, Taosheng Huang Current Status of Thalassemia in Minority Populations in Guanxi, China, Submitted
- 22. Mike Zaragoza, Mark Johnson, Stuart Schwartz and Taosheng Huang: Identification of a novel locus associated with autosomal dominant inherited isolated noncompaction of the ventricular myocardium, in preparation
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