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FACULTY

Adolescent Medicine
Allergy & Immunology
Cardiology
Critical Care/PICU
Endocrinology
General Pediatrics
Hematology/Oncology
Human Genetics & Metabolism
James Bartley, M.D., Ph.D.
Maureen Bocian, M.D.
Jose Camacho, M.D.
Kenneth W. Dumars, M.D.
Pamela Flodman, M.S., CGC
John Jay Gargus, M.D., Ph.D.
Taosheng Huang, M.D., Ph.D.
Virginia Kimonis, M.D.
Vincent Procaccio, M.D., Ph.D.
Roxanne Ruzicka, M.S., CGC
Moyra Smith, M.D., Ph.D.
M. Anne Spence, Ph.D.
Kathy Steinhaus French,MS,CGC
Ann Walker, M.A., CGC
Douglas C. Wallace, Ph.D.
Michael Zaragoza, M.D., Ph.D.

Infectious Disease
Neonatal/Perinatal Medicine
Nephrology
Neurology
Pulmonology
Child Development Center
General Clinical Research Center

• Position:
• Associate Clinical Professor of Pediatrics
• - Human Genetics Division & Metabolism


• EDUCATION


• Graduate Education:
• M.Sc., Oxford University
• M.S., University of California, Irvine


• HONORS & AWARDS


• Keasbey Memorial Foundation Fellowship, 1984-1986


• MEMBERSHIPS AND AFFILIATIONS


• Board Certifications:
• American Board of Medical Genetics - Genetic Counseling
• American Board of Genetic Counseling


• Professional Societies:
• American Society of Human Genetics
• National Society of Genetic Counselors


• SELECTED PUBLICATIONS:


• 1. Swanson JM, Oosterlaan J, Murias M, Schuck S, Flodman P, Spence MA, Wasdell M, Ding Y, Chi H-C, Smith M, Mann M, Carlson C, Kennedy MJ, Sergeant J, Leung P, Zhang Y-P, Sadeh A, Chen C, Moyzis R, and Posner MI. ADHD Children with a 7-Repeat Allele of the DRD4 Gene Have Extreme Behavior but Normal Performance on Critical Neuropsychological Tests of Attention. Proceedings of the National Academy of Sciences, 97(9):4754-9, 2000.


• 2. Martin RA, Hunter V, Neufeld-Kaiser W, Flodman P, Spence MA, Furnas D, Martin KA. Ultrasonographic detection of orbicularis oris defects in first degree relatives of isolated CL patients. American Journal of Medical Genetics, 90(2):155-61, 2000.


• 3. Flodman P, Hodge S. A Genetic Risk Calculation Surprise [letter to the Editor]. American Journal of Medical Genetics, 100(2):169-171, 2001.


• 4. Kelsoe JR, Spence MA, Loetscher E, Foguet M, Sadovnick AD, Remick RA, Flodman P, Khristich J, Mroczkowski-Parker Z, Brown JL, Masser D, Ungerleider S, Rapaport MH, and Luebbert H. A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22. PNAS, 98(2):585-90, 2001.


• 5. Flodman P, Macula AJ, Spence MA, and Torney DC. Preliminary implementation of new data mining techniques for the analysis of simulation data from GAW12: Problem 2. Genetic Epidemiology, 21(Suppl 1):S390-5, 2001.


• 6. Flodman P, Hodge S. A Genetic Risk Calculation Surprise [letter to the Editor]. American Journal of Medical Genetics, 100(2):169-171, 2001.


• 7. Kelsoe JR, Spence MA, Loetscher E, Foguet M, Sadovnick AD, Remick RA, Flodman P, Khristich J, Mroczkowski-Parker Z, Brown JL, Masser D, Ungerleider S, Rapaport MH, and Luebbert H. A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22. PNAS, 98(2):585-90, 2001.


• 8. Flodman P, Macula AJ, Spence MA, and Torney DC. Preliminary implementation of new data mining techniques for the analysis of simulation data from GAW12: Problem 2. Genetic Epidemiology, 21(Suppl 1):S390-5, 2001.


• 9. Flodman P, Ramos E, Rumbaugh M, Spence MA. The frequency of PKU mutants from published studies [technical report]. In: Report of the NIH Consensus Development Conference on Phenylketonuria (PKU): Screening and Management. Bethesda, Maryland, National Institutes of Health, A1-A43, January 2001.


• 10. Swanson J, Deutsch C, Cantwell D, Posner M, Kennedy J, Barr C, Moyzis R, Schuck S, Flodman P, Spence MA. Genes and attention-deficit hyperactivity disorder. Clinical Neuroscience Research, 1:207-16, 2001.


• 11. Smith M, Escamilla JR, Filipek P, Bocian ME, Modahl C, Flodman P, and Spence MA. Molecular genetic delineation of 2q37.3 deletion in autism and osteodystrophy: report of a case and of new markers for deletion screening by PCR. Cytogenet Cell Genet, 94(1-2):15-22, 2001.


• 12. Jaworski RL, Jirout M, Closson S, Breen L, Flodman PL, Spence MA, Kren V, Krenova D, Pravenec M, Printz MP. Heart Rate and Blood Pressure Quantitative Trait Loci for the Airpuff Startle Reaction. Hypertension, 39[part 2]:348-52, 2002.


• 13. Ding Y-C, Chi H-C, Grady DL, Morishima A, Kidd R, Kidd KK, Flodman P, Spence MA, Schuck S, Swanson JM, Zhang Y-P, and Moyzis RK. Evidence of positive selection acting at the human dopamine receptor D4 gene locus. PNAS, 99(1): 309-14, 2002.


• 14. Neiswanger K, Cooper ME, Weinberg SM, Flodman P, Bundens Keglovitz A, Liu Y-E, Hu D-N, Melnick M, Spence MA, and Marazita ML. Cleft Lip with or without Cleft Palate and Dermatoglyphic Asymmetry. Evaluation of a Chinese Population. Orthodontics and Craniofacial Research, 5:140-146, 2002.


• 15. Yu CE, Dawson G, Munson J, DSousa I, Osterling J, Estes A, Leutenegger AL, Flodman P, Smith M, Raskind WH, Spence MA, McMahon W, Wijsman EM, Schellenberg GD. Presence of Large deletions in kindreds with autism. Am J Hum Genet, 71(1):100-15, 2002.


• 16. Flodman P, Hodge SE. Determining complex genetic risks by computer. Journal of Genetic Counseling. 11(3):213-30, 2002.


• 17. Palmer AA, Breen LL, Flodman P, Conti LH, Spence MA, and Printz MP. Identification of Quantitative Trait Loci for Prepulse Inhibition in Rats. Psychopharmacology, 165(3):270-79, 2003.


• 18. Grady DL, Chi H-C, Ding Y-C, Smith M, Wang E, Schuck S, Flodman P, Spence MA, Swanson JM, and Moyzis RK. High Prevalance of Rare Dopamine Receptor D4 (DRD4) Alleles in Children Diagnosed with Attention Deficit Hyperactivity Disorder (ADHD). Molecular Psychiatry, 8(5):536-45, 2003.


• 19. Smith M, Woodroffe A, Smith RR, Holguin ST, Martinez J, Filipek PA, Modahl C, Moore B, Bocian ME, Mays L, Laulhere T, Flodman P, Spence MA. Molecular Genetic delineation of a deletion of chromosome 13q12-q13 in a patient with autism and auditory processing deficits. Cytogenetics and Genome Research, 98(4):233-9, 2002.


• 20. Goldberg WA, Osann K, Filipek PA, Laulhere T, Jarvis K, Modahl C, Flodman P, and Spence MA. Language and Other Regression: Assessment and Timing. Journal of Autism and Developmental Disorders, 33(6):607-16, 2003.


• 21. Flodman P, Hodge SE. Sex-specific mutation rates for X-linked disorders: Estimation and application. Human Heredity, 55(1):51-5, 2003.


• 22. Wang E, Ding YC, Flodman P, Kidd JR, Kidd KK, Grady DL, Ryder OA, Spence MA, Swanson JM, Moyzis RK. The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus. Am J Hum Genet. 2004 May;74(5):931-44.


• 23. Ramanathan S, Woodroffe A, Flodman PL, Mays LZ, Hanouni M, Modahl CB, Steinberg Epstein R, Bocian ME, Spence MA, Smith M. A case of autism with an interstitial deletion on 4q leading to hemizygosity for genes encoding for glutamine and glycine neurotransmitter receptor sub-units (AMPA 2, GLRA3, GLRB) and neuropeptide receptors NPY1R, NPY5R. BMC Med Genet. 2004 Apr 16;5(1):10.


• 24. Hodge SE, Flodman PL. Risk calculations: still essential in the molecular age. Am J Med Genet. 2004 Sep 1;129A(3):215-7.


• 25. Ogino S, Flodman P, Wilson RB, Gold B, Grody WW. Risk calculations for cystic fibrosis in neonatal screening by immunoreactive trypsinogen and CFTR mutation tests. Genet Med. 2005 May-Jun;7(5):317-27.


• 26. Grady DL, Harxhi A, Smith M, Flodman P, Spence MA, Swanson JM, Moyzis RK. Sequence variants of the DRD4 gene in autism: further evidence that rare DRD4 7R haplotypes are ADHD specific. Am J Med Genet B Neuropsychiatr Genet. 2005 Jul 5;136(1):33-5.


• 27. Leung PW, Lee CC, Hung SF, Ho TP, Tang CP, Kwong SL, Leung SY, Yuen ST, Lieh-Mak F, Oosterlaan J, Grady D, Harxhi A, Ding YC, Chi HC, Flodman P, Schuck S, Spence MA, Moyzis R, Swanson J. Dopamine receptor D4 (DRD4) gene in Han Chinese children with attention-deficit/hyperactivity disorder (ADHD): increased prevalence of the 2-repeat allele. Am J Med Genet B Neuropsychiatr Genet. 2005 Feb 5;133(1):54-6.


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