Peter Steyger from OHSU will speak to us this
Tuesday, Nov 13 at 3 p.m. in Nat. Sci. II room 4201.
Aminoglycoside trafficking across the
blood-labyrinth barrier to hair cells
Abstract:
Aminoglycosides are critical for treating
meningitis, and prophylaxis in severe injuries, but have serious side
effects, causing ototoxicity and nephrotoxicity.
In the inner ear, aminoglycosides enter sensory hair cells across the
apical, endolymphatic membranes, including the mechano-electrical
transduction channel, in vitro. This implies that the toxic route of
aminoglycosides into hair cells is primarily from endolymph in vivo.
This presentation will discuss the different possible routes by which
aminoglycosides enter endolymph in vivo.