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| Dr. Ribak's Research Description |
 (Click Image to View) Photomicropraphs of preparations from the right and left sides of the hippocampus. |
 (Click Image to View) Massive sprouting of mossy fibers into the inner molecular layer of the dentate gyrus in hippocampus. |
 (Click Image to View) Low magnification of the dentate gyrus |
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Primary
Research Interests
Ribak's recent research has concentrated on temporal lobe epilepsy, both in monkeys and rats. Temporal lobe epilepsy typically arises from the hippocampus and is one of the most difficult types of epilepsy to treat with antiepileptic drugs. Most humans with this form of epilepsy require neurosurgical intervention, usually a temporal lobectomy. Ribak's research team developed the first primate temporal lobe epilepsy model that mimics the behavioral, electroencephalographic and pathological changes found in human temporal lobe epilepsy. In the rat, Ribak has recently shown that following experimentally-induced temporal lobe epilepsy a neuroplastic change occurs with granule cells in the hippocampal dentate gyrus. They form basal dendrites that are involved in additional recurrent excitatory circuitry that may underlie the spontaneous seizures found in these experimental animals. In addition, hilar ectopic granule cells have been shown to increase in the brains of epileptic rats. These neurons also contribute additional recurrent excitatory circuitry. |
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