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| Dr. O'Dowd's Lab - Image #3 |
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Spontaneous Synaptic
Transmission Whole-cell recordings demonstrate that the synaptic currents recorded in neurons from the brains of fruitflies and mice are very similar. In both animals, inhibitory synaptic transmission is relatively slow and mediated by GABA. Excitatory synaptic transmission in both animals in kinetically fast but the predominant form is cholinergic in the fly and glutamatergic in the mouse. Our recent studies show that cAMP regulates plasticity at these neuronal synapses in Drosophila as they do in mice. We are using a combination of molecular, genetic, and electrophysiological approaches to further explore the mechanisms important in regulating synaptic activity in both flies and mice. |
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